Preheat oven to 350-degrees F. Place cupcake papers in muffin tins; set aside.
In a medium-size mixing bowl, whisk together flour, baking powder, baking soda and salt; set aside.
Slice vanilla bean in half lengthwise. With the dull side of knife, scrape the vanilla caviar from each bean half.
In the bowl of a stand mixer, with the paddle attachment beat vanilla bean caviar, butter and sugar until light and fluffy, about 4-5 minutes.
Add eggs, one at a time, beating well after each addition.
In a measuring cup with a pour spout, stir together the buttermilk, milk and vanilla.
Stir approximately 1/3 of flour mixture into the butter/sugar mixture followed by 1/3 of the buttermilk mixture. Repeat twice more, stirring just until ingredients are well blended. Do not over-mix. The batter is relatively thick.
Using an ice cream scoop (or a ¼ cup measuring cup), scoop batter into prepared muffin tins.Tap the tins against the counter top several times to help settle the batter and release any large air bubbles which may be caught in the thick batter.
Bake for 15 minutes or until a toothpick inserted into the center of several cupcakes comes out clean. Please note: When done, the cupcakes should be pale on top and will spring back when lightly touched. Be careful not to over bake. Over baking will cause the cupcakes to be dry. If using two pans in the same oven at the same time, rotate pans halfway through baking time.
Allow baked cupcakes to cool in muffin tins for about 5 minutes. Remove cupcakes from tins and place on cooling rack. When cool, frost as desired.